Below is a list of feature films that Glenn Howerton has starred in. They are listed in reverse-chronological order, with the most recent ones last. Click on the titles to read more about each project individually.
| 2002 | Monday Night Mayhem | Dick Ebersol |
| 2003 | E.D.N.Y. | Paul Webster |
| 2005 | Must Love Dogs | Michael |
| 2005 | Serenity | Lilac Young Tough |
| 2006 | Crank | Doctor |
| 2006 | Two Weeks | Matthew Bergman |
| 2008 | The Strangers | Mike |
| 2008 | Happy Wednesday (Short) | Spencer Scott |
| 2009 | Crank: High Voltage | Doctor (uncredited) |
| 2010 | Everything Must Go | Gary |
| 2011 | Happy Cabin Song (Short) | |
| 2013 | Coffee Town | Will |
| 2016 | Officer Downe | Dominic |
| 2017 | When Pigs Fly (Short) | Uncle Al |
| 2019 | The Hunt | |
| El Tonto |